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Bubble electrodeposition of gold porous nanocorals for the enzymatic and non-enzymatic detection of glucose.

Authors
  • Sanzó, Gabriella1
  • Taurino, Irene2
  • Antiochia, Riccarda3
  • Gorton, Lo4
  • Favero, Gabriele5
  • Mazzei, Franco5
  • De Micheli, Giovanni2
  • Carrara, Sandro2
  • 1 Laboratory of Integrated Systems, EPFL - École Polytechnique Fédérale de Lausanne, 1015 Lausanne, Switzerland; Biosensors Laboratory, Department of Chemistry and Drug Technologies, Sapienza University of Rome, P.le Aldo Moro, 5-00185 Roma, Italy. Electronic address: [email protected]
  • 2 Laboratory of Integrated Systems, EPFL - École Polytechnique Fédérale de Lausanne, 1015 Lausanne, Switzerland.
  • 3 Biosensors Laboratory, Department of Chemistry and Drug Technologies, Sapienza University of Rome, P.le Aldo Moro, 5-00185 Roma, Italy. Electronic address: [email protected]
  • 4 Department of Analytical Chemistry/Biochemistry, P.O. Box 124, 221 00 Lund, Sweden.
  • 5 Biosensors Laboratory, Department of Chemistry and Drug Technologies, Sapienza University of Rome, P.le Aldo Moro, 5-00185 Roma, Italy.
Type
Published Article
Journal
Bioelectrochemistry (Amsterdam, Netherlands)
Publication Date
December 2016
Volume
112
Pages
125–131
Identifiers
DOI: 10.1016/j.bioelechem.2016.02.012
PMID: 27008973
Source
Medline
Keywords
License
Unknown

Abstract

Au nanocorals are grown on gold screen-printed electrodes (SPEs) by using a novel and simple one-step electrodeposition process. Scanning electron microscopy was used for the morphological characterization. The devices were assembled on a three-electrode SPE system, which is flexible and mass producible. The electroactive surface area, determined by cyclic voltammetry in sulphuric acid, was found to be 0.07±0.01cm(2) and 35.3±2.7cm(2) for bare Au and nanocoral Au, respectively. The nanocoral modified SPEs were used to develop an enzymatic glucose biosensor based on H2O2 detection. Au nanocoral electrodes showed a higher sensitivity of 48.3±0.9μA/(mMcm(2)) at +0.45V vs Ag|AgCl compared to a value of 24.6±1.3μA/(mMcm(2)) at +0.70V vs Ag|AgCl obtained with bare Au electrodes. However, the modified electrodes have indeed proven to be extremely powerful for the direct detection of glucose with a non-enzymatic approach. The results confirmed a clear peak observed by using nanocoral Au electrode even in the presence of chloride ions at physiological concentration. Amperometric study carried out at +0.15V vs Ag|AgCl in the presence of 0.12M NaCl showed a linear range for glucose between 0.1 and 13mM.

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