Affordable Access

deepdyve-link
Publisher Website

Brown Tumors Due to Primary Hyperparathyroidism in a Patient with Parathyroid Carcinoma Mimicking Skeletal Metastases on (18)F-FDG PET/CT.

Authors
  • Andersen, Kim Francis1
  • Albrecht-Beste, Elisabeth2
  • 1 Department of Clinical Physiology, Nuclear Medicine & PET, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9-PET 3982, DK-2100 Copenhagen, Denmark. [email protected] , (Denmark)
  • 2 Department of Clinical Physiology, Nuclear Medicine & PET, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9-PET 3982, DK-2100 Copenhagen, Denmark. [email protected] , (Denmark)
Type
Published Article
Journal
Diagnostics
Publisher
MDPI AG
Publication Date
Jul 09, 2015
Volume
5
Issue
3
Pages
290–293
Identifiers
DOI: 10.3390/diagnostics5030290
PMID: 26854155
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Parathyroid carcinoma only represents <1% of all cases of primary hyperparathyroidism (PHPT). Even rare, chronic PHPT may lead to excessive osteoclast activity, and the increased resorption leads to destruction of cortical bone and formation of fibrous cysts with deposits of hemosiderin-so-called brown tumors. These benign, osteolytic lesions may demonstrate FDG-avidity on (18)F-FDG PET/CT, and as such are misinterpreted as skeletal metastases. Regression of the lesions may occur following successful treatment. We present a case demonstrating the diagnostic work-up and follow-up of a patient with PHPT due to parathyroid carcinoma and with presence of brown tumors on (18)F-FDG PET/CT, visualizing the possible role of this imaging modality in the evaluation of treatment response in these patients.

Report this publication

Statistics

Seen <100 times