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Bronchoalveolar lavage in asthmatic children: evidence of neutrophil activation in mild-to-moderate persistent asthma.

Authors
  • Barbato, A
  • Panizzolo, C
  • Gheno, M
  • Sainati, L
  • Favero, E
  • Faggian, D
  • Giusti, F
  • Pesscolderungg, L
  • La Rosa, M
Type
Published Article
Journal
Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology
Publication Date
Apr 01, 2001
Volume
12
Issue
2
Pages
73–77
Identifiers
PMID: 11338289
Source
Medline
License
Unknown

Abstract

Little information is available on cell profiles and mediator production in the lower airways of children with asthma by comparison with the adult population. To study the bronchoalveolar lavage (BAL) cell profiles and production of eosinophil cationic protein (ECP) and myeloperoxidase (MPO) in childhood bronchial asthma, a retrospective study was performed in 29 children (13 allergic asthmatic children and 16 controls). Six of the asthmatics had mild-to-moderate persistent disease and seven had intermittent asthma. The BAL cell count and ECP and MPO values of asthmatic children were compared with those from 16 controls. The asthmatic patients had higher values than controls for the total cell count (p = 0.08), for neutrophils (p = 0.02), and for ECP and MPO (p < 0.001). MPO levels (p = 0.04), neutrophil count (p = 0.06), and ECP values (p = 0.06) were higher in patients with mild-to-moderate persistent asthma than in those with intermittent asthma. Our results demonstrate that neutrophil-mediated inflammation is greater in patients with more severe asthma.

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