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Broncho Alveolar Dendritic Cells and Macrophages Are Highly Similar to Their Interstitial Counterparts.

Authors
  • Maisonnasse, Pauline1
  • Bordet, Elise1
  • Bouguyon, Edwige1
  • Bertho, Nicolas1
  • 1 Virologie et Immunologie Moléculaires, Institut National de la Recherche Agronomique, Domaine de Vilvert, Jouy-en-Josas, France. , (France)
Type
Published Article
Journal
PLoS ONE
Publisher
Public Library of Science
Publication Date
Jan 01, 2016
Volume
11
Issue
12
Identifiers
DOI: 10.1371/journal.pone.0167315
PMID: 27992536
Source
Medline
Language
English
License
Unknown

Abstract

In human medicine, bronchoalveolar lavage is the main non-traumatic procedure allowing an insight into the respiratory Dendritic Cells (DC) and Macrophages populations. However, it has never been demonstrated in a relevant model that alveolar DC subpopulations were comparable to their interstitial counterparts. In a precedent work we observed that respiratory pig DC and Macrophages were more similar to the human ones than to the mouse ones. In the present work, thanks to our animal model, we were able to collect the rare bronchoalveolar DC and compare them to their interstitial counterparts. We observed that DC presented very similar gene-expression patterns in the alveolar and interstitial compartments, validating the study of human bronchoalveolar DC as surrogate of their interstitium counterparts.

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