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Broad-spectrum beta-lactam antibiotics with beta-lactamase inhibitors.

Authors
  • Muñoz, P1
  • García-Garrote, F
  • Bouza, E
  • 1 Department of Clinical Microbiology and Infectious Diseases, Hospital General Universitario 'Gregorio Mararañón', Madrid, Spain. , (Spain)
Type
Published Article
Journal
International Journal of Antimicrobial Agents
Publisher
Elsevier
Publication Date
Jun 01, 1996
Volume
7 Suppl 1
Identifiers
PMID: 18611777
Source
Medline
License
Unknown

Abstract

Combining cefoperazone, piperacillin or ticarcillin with the beta-lactamase inhibitors sulbactam, tazobactam or clavulanic acid, respectively, results in compounds with activity against a wide range of Gram-positive and Gram-negative aerobic and anaerobic organisms, including strains producing beta-lactamases. Pharmacokinetics of the three combinations are similar. Cefoperazone/sulbactam can be given twice daily as opposed to a minimum of three-times-daily dosing required with the other combinations. All 9 combinations have a good safety profile, and may be administered parenterally for the treatment of severe infections in hospitalized patients, including intra-abdominal, gynaecological, skin and soft tissue infections. Additional cover may be provided by administering one of these combinations with an aminoglycoside.

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