Affordable Access

deepdyve-link
Publisher Website

Broad Spectrum Antiviral Agent Niclosamide and Its Therapeutic Potential.

Authors
  • Xu, Jimin
  • Shi, Pei-Yong
  • Li, Hongmin1
  • Zhou, Jia
  • 1 Wadsworth Center, New York State Department of Health, 120 New Scotland Avenue, Albany, New York 12208, United States. , (United States)
Type
Published Article
Journal
ACS Infectious Diseases
Publisher
American Chemical Society
Publication Date
Mar 10, 2020
Identifiers
DOI: 10.1021/acsinfecdis.0c00052
PMID: 32125140
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

The recent outbreak of coronavirus disease 2019 (COVID-19) highlights an urgent need for therapeutics. Through a series of drug repurposing screening campaigns, niclosamide, an FDA-approved anthelminthic drug, was found to be effective against various viral infections with nanomolar to micromolar potency such as SARS-CoV, MERS-CoV, ZIKV, HCV, and human adenovirus, indicating its potential as an antiviral agent. In this brief review, we summarize the broad antiviral activity of niclosamide and highlight its potential clinical use in the treatment of COVID-19.

Report this publication

Statistics

Seen <100 times