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Bridging the gap between in vitro and in vivo models for neurotoxicology.

Authors
  • Tiffany-Castiglioni, E1
  • Ehrich, M
  • Dees, L
  • Costa, L G
  • Kodavanti, P R
  • Lasley, S M
  • Oortgiesen, M
  • Durham, H D
  • 1 Department of Veterinary Anatomy and Public Health, Texas A&M University, College Station 77843, USA. [email protected]
Type
Published Article
Journal
Toxicological Sciences
Publisher
Oxford University Press
Publication Date
October 1999
Volume
51
Issue
2
Pages
178–183
Identifiers
PMID: 10543019
Source
Medline
License
Unknown

Abstract

In vitro systems are widely used for investigation of neurotoxicant-induced perturbations of cellular functions. A variety of systems exist that demonstrate certain similarities to neurotoxicant-induced events in the intact animal are discussed, including single-cell types, systems that consider endpoints relevant in toxicology, and systems that consider heterogeneous cell interactions. Relationships between the in vitro and in vivo systems are examined in which ethanol, lead, polychlorinated biphenyl compounds, and organophosphate insecticides are examples. Situations in which the in vitro systems have been used to advantage are provided, along with cautions associated with their use.

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