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Breast carcinogenesis. Transition from hyperplasia to invasive lesions.

Authors
Type
Published Article
Journal
Saudi Medical Journal
0379-5284
Publisher
Saudi Medical Journal
Publication Date
Volume
26
Issue
12
Pages
1889–1896
Identifiers
PMID: 16380768
Source
Medline

Abstract

As a result, it has been shown that together with increase in proliferation, decrease in apoptosis, too, contributes to the proliferation/apoptosis imbalance that occurs in breast carcinogenesis. Increase in proliferation and decrease in apoptosis are parallel with the progression of lesions. We also showed that the changes, beginning with loss of ER and PR in ADH step, can cause malign transformation, which is especially notable both in DCIS step due to Ki-67 and c-erbB2 increase, and also with bcl-2 and TUNEL decrease.

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