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Breast cancer risk during HRT: influence of estradiol metabolites on breast cancer and endothelial cell proliferation.

Authors
  • Seeger, Harald
  • Deuringer, Fritz-Ulrich
  • Wallwiener, Diethelm
  • Mueck, Alfred O
Type
Published Article
Journal
Maturitas
Publisher
Elsevier
Publication Date
Nov 15, 2004
Volume
49
Issue
3
Pages
235–240
Identifiers
PMID: 15488352
Source
Medline
License
Unknown

Abstract

These results indicate that certain endogenous estradiol metabolites are able to stimulate breast cancer cell proliferation, and others may be suitable for breast cancer treatment when used in high dosages, since they inhibit cancer cell growth as well as neoangiogensis. This may be of special importance for therapy, since some of these metabolites are virtually devoid of any oestrogenic activity.

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