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Breast cancer with an intraductal component that was proven genetically to be metastasis of contralateral breast cancer: a case report

Authors
  • Shinden, Yoshiaki1
  • Saho, Hazuki1
  • Nomoto, Yuki1
  • Nagata, Ayako1
  • Minami, Koji1
  • Nakajo, Akihiro1
  • Akahane, Toshiaki2
  • Hiraki, Tsubasa2
  • Tanimoto, Akihide2
  • Owaki, Tetsuhiro2
  • Kijima, Yuko3
  • Natsugoe, Shoji1
  • 1 Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1, Sakuragaoka, Kagoshima, 890-8520, Japan , Kagoshima (Japan)
  • 2 Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan , Kagoshima (Japan)
  • 3 Fujita Health University, Toyoake, Japan , Toyoake (Japan)
Type
Published Article
Journal
Surgical Case Reports
Publisher
Springer Berlin Heidelberg
Publication Date
Aug 24, 2020
Volume
6
Issue
1
Identifiers
DOI: 10.1186/s40792-020-00966-y
Source
Springer Nature
Keywords
License
Green

Abstract

BackgroundWhen diagnosing patients with bilateral breast cancer, it is challenging to determine the relationship between multiple breast cancer lesions at the individual patient level with certainty.Case presentationA 35-year-old Japanese woman was diagnosed with a left breast cancer. She was previously diagnosed with right pT3N3M0 stage IIIC breast cancer and underwent chemotherapy with targeted therapy, radiotherapy, and endocrine therapy as adjuvant treatment after mastectomy and axillary lymph node dissection. Approximately 2 years after the first surgery, her left breast cancer was preoperatively diagnosed as a contralateral primary breast cancer, and left mastectomy and axillary lymph node dissection were performed. Histopathologically, the tumor was determined to be invasive ductal carcinoma accompanied with several intraductal components. After a second surgery, mutation analysis of her bilateral breast cancer was performed in a clinical study, which revealed that her metachronous bilateral breast tumors had the same GATA3 and CSMD1 mutations. Thus, mutation analysis strongly supported her latter left breast cancer being a metastatic lesion from the former right breast cancer. Some difficulties in diagnosing bilateral breast cancer exist when determining whether they are double primary cancers or represent contralateral breast metastasis. The existence of intraductal components is a critical piece of information for suspecting primary lesions. However, this case demonstrated that metastatic contralateral breast lesions can have intraductal components.ConclusionHerein we report a genetically proven contralateral breast metastasis with some intraductal components.

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