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Breaking the wall: targeting of the endothelium by pathogenic bacteria.

Authors
Type
Published Article
Journal
Nature Reviews Microbiology
Publisher
Springer Nature
Publication Date
Feb 27, 2010
Volume
8
Issue
2
Pages
93–104
Identifiers
DOI: 10.1038/nrmicro2269
PMID: 20040916
Source
USPC - SET - SVS
License
White

Abstract

The endothelium lining blood and lymphatic vessels is a key barrier separating body fluids from host tissues and is a major target of pathogenic bacteria. Endothelial cells are actively involved in host responses to infectious agents, producing inflammatory cytokines, controlling coagulation cascades and regulating leukocyte trafficking. In this Review, a range of bacteria and bacterial toxins are used to illustrate how pathogens establish intimate interactions with endothelial cells, triggering inflammatory responses and coagulation processes and modifying endothelial cell plasma membranes and junctions to adhere to their surfaces and then invade, cross and even disrupt the endothelial barrier.

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