The bubble breakage rate in gas-liquid bubble columns increases for organic liquid and at high pressure. This study developed a breakage model that accounts for different liquid properties in gas-liquid pressurized bubble columns in the homogeneous regime. The Luo (1996), Lehr (2002), and Wang (2003) breakage models, which are widely used for the population balance equation (PBE) of bubble columns, were compared in terms of the total breakage rate, daughter size distribution, and computational time. The model with two empirical equations, modified from Luo’s breakage kernel, was proposed. One represented bubble deformation behavior in different liquid properties in terms of buoyancy, surface tension, and viscosity. The other considered the effect of operating pressure (or gas density) on the breakage rate. The modified model was compared with experimental data and a rigorous breakage model from the literature. The proposed breakage model shows good agreement with experimental data and computational efficiency. This breakage model is applicable for computational fluid dynamics with PBE in pressurized bubble columns with organic liquids.