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A Brainstem Locomotor Circuit Drives the Activity of Speed Cells in the Medial Entorhinal Cortex

Authors
  • Carvalho, Miguel M.1
  • Tanke, Nouk1
  • Kropff, Emilio2
  • Witter, Menno P.1
  • Moser, May-Britt1
  • Moser, Edvard I.1
  • 1 Kavli Institute for Systems Neuroscience and Centre for Neural Computation, Norwegian University of Science and Technology, Olav Kyrres Gate 9, 7491 Trondheim, Norway
  • 2 Leloir Institute, IIBBA – CONICET, Av. Patricias Argentinas 435, Buenos Aires CP C1405BWE, Argentina
Type
Published Article
Journal
Cell Reports
Publisher
Elsevier
Publication Date
Sep 08, 2020
Volume
32
Issue
10
Identifiers
DOI: 10.1016/j.celrep.2020.108123
PMID: 32905779
PMCID: PMC7487772
Source
PubMed Central
Keywords
License
Unknown

Abstract

Carvalho et al. describe a brain circuit in rats that conveys information about locomotion speed from the brainstem to cortical structures implicated in navigation. Optogenetic activation of the brainstem’s pedunculopontine nucleus drives locomotion and modulates speed-modulated neurons in the diagonal band of Broca and the medial entorhinal cortex.

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