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Brains, Blood, and Guts: MeCP2 Regulates Microglia, Monocytes, and Peripheral Macrophages.

Authors
  • Schafer, Dorothy P1
  • Stevens, Beth2
  • 1 Department of Neurobiology, University of Massachusetts Medical School, Worcester, MA 01605, USA. Electronic address: [email protected]
  • 2 Department of Neurology, F.M. Kirby Neurobiology Center, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115.
Type
Published Article
Journal
Immunity
Publication Date
Apr 21, 2015
Volume
42
Issue
4
Pages
600–602
Identifiers
DOI: 10.1016/j.immuni.2015.04.002
PMID: 25902477
Source
Medline
License
Unknown

Abstract

Mutations in methyl-CpG-binding protein 2 (MECP2) underlie most cases of Rett Syndrome, a neurodevelopmental disorder with neurological and somatic impairments. In this issue of Immunity, Cronk et al. (2015) find that macrophages in MeCP2-deficient mice are abnormal in number, as well as in glucocorticoid, hypoxia, and inflammatory responses.

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