Brains, Blood, and Guts: MeCP2 Regulates Microglia, Monocytes, and Peripheral Macrophages.
Department of Neurobiology, University of Massachusetts Medical School, Worcester, MA 01605, USA. Electronic address: [email protected]
Department of Neurology, F.M. Kirby Neurobiology Center, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115.
- Published Article
- Publication Date
Apr 21, 2015
Mutations in methyl-CpG-binding protein 2 (MECP2) underlie most cases of Rett Syndrome, a neurodevelopmental disorder with neurological and somatic impairments. In this issue of Immunity, Cronk et al. (2015) find that macrophages in MeCP2-deficient mice are abnormal in number, as well as in glucocorticoid, hypoxia, and inflammatory responses.
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The corresponding record at NLM can be accessed at https://www.ncbi.nlm.nih.gov/pubmed/25902477