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Brain structural substrates of reward dependence during behavioral performance.

Authors
Type
Published Article
Journal
Journal of Neuroscience
0270-6474
Publisher
Society for Neuroscience
Publication Date
Volume
34
Issue
49
Pages
16433–16441
Identifiers
DOI: 10.1523/JNEUROSCI.3141-14.2014
PMID: 25471581
Source
Medline
Keywords
  • Brain Structure
  • Motivation
  • Prefrontal Cortex
  • Reward

Abstract

Interindividual differences in the effects of reward on performance are prevalent and poorly understood, with some individuals being more dependent than others on the rewarding outcomes of their actions. The origin of this variability in reward dependence is unknown. Here, we tested the relationship between reward dependence and brain structure in healthy humans. Subjects trained on a visuomotor skill-acquisition task and received performance feedback in the presence or absence of reward. Reward dependence was defined as the statistical trial-by-trial relation between reward and subsequent performance. We report a significant relationship between reward dependence and the lateral prefrontal cortex, where regional gray-matter volume predicted reward dependence but not feedback alone. Multivoxel pattern analysis confirmed the anatomical specificity of this relationship. These results identified a likely anatomical marker for the prospective influence of reward on performance, which may be of relevance in neurorehabilitative settings.

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