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Brain Stimulation Differentially Modulates Nociception and Inflammation in Aversive and Non-aversive Behavioral Conditions.

Authors
  • Bassi, G S1
  • Kanashiro, A2
  • Rodrigues, G J2
  • Cunha, F Q3
  • Coimbra, N C4
  • Ulloa, L5
  • 1 Department of Immunology, Ribeirão Preto Medical School of the University of São Paulo, Ribeirão Preto, São Paulo, Brazil; Yueyang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200030, China. Electronic address: [email protected] , (Brazil)
  • 2 Department of Physiological Sciences, Federal University of São Carlos, São Carlos, São Paulo, Brazil. , (Brazil)
  • 3 Department of Pharmacology, Ribeirão Preto Medical School of the University of São Paulo, Ribeirão Preto, São Paulo, Brazil. , (Brazil)
  • 4 Department of Pharmacology, Ribeirão Preto Medical School of the University of São Paulo, Ribeirão Preto, São Paulo, Brazil; NAP-USP-Neurobiology of Emotions Research Centre (NuPNE), Ribeirão Preto Medical School of the University of São Paulo, São Paulo, Brazil. Electronic address: [email protected] , (Brazil)
  • 5 Yueyang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200030, China; Department of Surgery, Centre for Immunology and Inflammation, Rutgers - New Jersey Medical School, Rutgers University, Newark, NJ 07103, USA. Electronic address: [email protected] , (China)
Type
Published Article
Journal
Neuroscience
Publication Date
May 18, 2018
Volume
383
Pages
191–204
Identifiers
DOI: 10.1016/j.neuroscience.2018.05.008
PMID: 29772343
Source
Medline
Keywords
License
Unknown

Abstract

Inflammation and pain are major clinical burdens contributing to multiple disorders and limiting the quality of life of patients. We previously reported that brain electrical stimulation can attenuate joint inflammation in experimental arthritis. Here, we report that non-aversive electrical stimulation of the locus coeruleus (LC), the paraventricular hypothalamic nucleus (PVN) or the ventrolateral column of the periaqueductal gray matter (vlPAG) decreases thermal pain sensitivity, knee inflammation and synovial neutrophilic infiltration in rats with intra-articular zymosan. We also analyzed the modulation of pain and inflammation during aversive neuronal stimulation, which produces defensive behavioral responses such as freezing immobility to avoid predator detection. Electrical stimulation with higher intensity to induce freezing immobility in rats further reduces pain but not inflammation. However, tonic immobility further reduces pain, knee inflammation and synovial neutrophilic infiltration in guinea pigs. The duration of the tonic immobility increases the control of pain and inflammation. These results reveal survival behavioral and neuromodulatory mechanisms conserved in different species to control pain and inflammation in aversive life-threatening conditions. Our results also suggest that activation of the LC, PVN, or vlPAG by non-invasive methods, such as physical exercise, meditation, psychological interventions or placebo treatments may reduce pain and joint inflammation in arthritis without inducing motor or behavioral alterations.

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