Affordable Access

Access to the full text

Brain size and folding of the human cerebral cortex.

Authors
  • Roberto Toro
  • Perron, Michel
  • Pike, Bruce
  • Richer, Louis
  • Veillette, Suzanne
  • Pausova, Zdenka
  • Paus, Tomás
Type
Published Article
Journal
Cerebral Cortex
Publisher
Oxford University Press (OUP)
Publication Date
Feb 22, 2008
Volume
18
Issue
10
Pages
2352–2357
Identifiers
DOI: 10.1093/cercor/bhm261
PMID: 18267953
Source
USPC - SET - SVS
License
Green

Abstract

During evolution, the mammalian cerebral cortex has expanded disproportionately to brain volume. As a consequence, most mammals with large brains have profusely convoluted cortices. The human cortex is a good example of this trend, however, given the large variability in human brain size, it is not clear how cortical folding varies from the smallest to the largest brains. We analyzed cortical folding in a large cohort of human subjects exhibiting a 1.7-fold variation in brain volume. We show that the same disproportionate increase of cortical surface relative to brain volume observed across species can be also observed across human brains: the largest brains can have up to 20% more surface than a scaled-up small brain. We introduce next a novel local measure of cortical folding, and we show that the correlation between cortical folding and size varies along a rostro-caudal gradient, being especially significant in the prefrontal cortex. The expansion of the cerebral cortex, and in particular that of its prefrontal region, is a major evolutionary landmark in the emergence of human cognition. Our results suggest that this may be, at least in part, a natural outcome of increasing brain size.

Report this publication

Statistics

Seen <100 times