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Brain Natriuretic Peptide in Term Pregnancy

Authors
  • Yurteri-Kaplan, Ladin1
  • Saber, Shelley1
  • Zamudio, Stacy1
  • Srinivasan, Deepak1
  • Nyirenda, Themba1
  • Alvarez, Manuel1
  • AL-KHAN, Abdulla1
  • 1 Hackensack University Medical Center, University of Medicine and Dentistry of New Jersey-–New Jersey Medical School, Hackensack, NJ, USA , Hackensack (United States)
Type
Published Article
Journal
Reproductive Sciences
Publisher
SAGE Publications
Publication Date
May 01, 2012
Volume
19
Issue
5
Pages
520–525
Identifiers
DOI: 10.1177/1933719111426598
Source
Springer Nature
Keywords
License
Yellow

Abstract

ObjectiveTo determine the normal range of serum brain natriuretic peptide (BNP) in uncomplicated, singleton term pregnant patients.Study DesignSerum for analysis of BNP was drawn at admission to labor and delivery (= 104), prior to administration of intravenous fluid.ResultsMedian BNP was 20 pg/mL, with an interquartile range of 20 pg/mL (range 5–70 pg/mL; or a mean ± standard deviation [SD] of 23 ± 16 pg/mL). Brain natriuretic peptide negatively correlated with prepregnant (r = −.24, P < .05) and pregnant weight (r = −26, P < .01) and with heart rate (r = −.35, P < 0.001); heart rate was also positively correlated with BMI (r = .32). Brain natriuretic peptide levels were higher in Hispanic than African American women, independent of body mass index (BMI) and heart rate.ConclusionsBrain natriuretic peptide values found in term pregnant patients are similar to those of prepregnant women of reproductive age. Brain natriuretic peptide levels appear to be set by conditions present in the prepregnant condition and maintained, despite changes in plasma volume, systemic vascular resistance, and cardiac output.

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