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Brain metabolite values in children with breath-holding spells.

Authors
  • Calik, Mustafa1
  • Sen Dokumaci, Dilek2
  • Sarikaya, Suna3
  • Demir, Mahmut4
  • Isik, Ilhan5
  • Kazanasmaz, Halil4
  • Kaya, Cemil4
  • Kandemir, Hasan6
  • 1 Department of Pediatric Neurology.
  • 2 Department of Radiology.
  • 3 Department of Neurology.
  • 4 Department of Pediatrics, Harran University School of Medicine.
  • 5 Department of Pediatric Neurology, Eyyubiye Training and Research Hospital.
  • 6 Department of Child and Adolescent Psychiatry, Harran University School of Medicine, Sanliurfa, Turkey. , (Turkey)
Type
Published Article
Journal
Neuropsychiatric Disease and Treatment
Publisher
Dove Medical Press
Publication Date
Jan 01, 2017
Volume
13
Pages
1655–1660
Identifiers
DOI: 10.2147/NDT.S135842
PMID: 28721046
Source
Medline
Keywords
License
Unknown

Abstract

Breath-holding spells are benign, paroxysmal events with apnea and postural tone changes after a crying episode in infants. The objective of this study was to investigate the pathologies in brain metabolite values in the absence of seizure in children with breath-holding spells by using magnetic resonance spectroscopy (MRS). Brain MRS examination was performed on 18 children with breath-holding spells and 13 neurologically normal children who were included as the control group. There was no significant difference in terms of N-acetyl aspartate (NAA), choline (Cho), creatine (Cr), and myoinositol (mI) levels and also in terms of NAA/Cr, Cho/Cr, and mI/Cr ratios between the patients and the control group (all P>0.05). Our study suggested that there is no permanent neuronal damage in patients with breath-holding spells. This result confirms the previous studies, which reported no permanent neuronal damage in patients with breath-holding spells.

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