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Brain Graph Topology Changes Associated with Anti-Epileptic Drug Use.

Authors
  • Haneef, Zulfi1, 2
  • Levin, Harvey S3
  • Chiang, Sharon4
  • 1 1 Department of Neurology, Baylor College of Medicine , Houston, Texas.
  • 2 2 Neurology Care Line, VA Medical Center , Houston, Texas.
  • 3 3 Department of Physical Medicine, Baylor College of Medicine , Houston, Texas.
  • 4 4 Department of Statistics, Rice University , Houston, Texas.
Type
Published Article
Journal
Brain connectivity
Publication Date
Jun 01, 2015
Volume
5
Issue
5
Pages
284–291
Identifiers
DOI: 10.1089/brain.2014.0304
PMID: 25492633
Source
Medline
Keywords
License
Unknown

Abstract

Neuroimaging studies of functional connectivity using graph theory have furthered our understanding of the network structure in temporal lobe epilepsy (TLE). Brain network effects of anti-epileptic drugs could influence such studies, but have not been systematically studied. Resting-state functional MRI was analyzed in 25 patients with TLE using graph theory analysis. Patients were divided into two groups based on anti-epileptic medication use: those taking carbamazepine/oxcarbazepine (CBZ/OXC) (n=9) and those not taking CBZ/OXC (n=16) as a part of their medication regimen. The following graph topology metrics were analyzed: global efficiency, betweenness centrality (BC), clustering coefficient, and small-world index. Multiple linear regression was used to examine the association of CBZ/OXC with graph topology. The two groups did not differ from each other based on epilepsy characteristics. Use of CBZ/OXC was associated with a lower BC. Longer epilepsy duration was also associated with a lower BC. These findings can inform graph theory-based studies in patients with TLE. The changes observed are discussed in relation to the anti-epileptic mechanism of action and adverse effects of CBZ/OXC.

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