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Brain-derived neurotrophic factor serum levels in alcohol-dependent subjects 6 months after alcohol withdrawal.

Authors
  • Costa, Marie-Agnès
  • Girard, Murielle
  • Dalmay, François
  • Malauzat, Dominique
Type
Published Article
Journal
Alcoholism Clinical and Experimental Research
Publisher
Wiley (Blackwell Publishing)
Publication Date
Nov 01, 2011
Volume
35
Issue
11
Pages
1966–1973
Identifiers
DOI: 10.1111/j.1530-0277.2011.01548.x
PMID: 21848960
Source
Medline
License
Unknown

Abstract

Our data confirm that serum BDNF levels do not correlate with either chronic alcohol consumption or peripheral toxicity but may be linked to neuronal aspects of alcohol consumption and dependence. The increased serum levels of BDNF may reflect the concomitant activation of BDNF synthesis that accompanies the neuronal remodeling triggered by alcohol withdrawal and suggests that BDNF synthesis may have a role in the long-term maintenance of abstinence. Monitoring the serum BDNF levels of alcoholics undergoing treatment could help to characterize alcohol dependence profiles and predict relapse.

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