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Brain atrophy after immunoablation and stem cell transplantation in multiple sclerosis.

Authors
Type
Published Article
Journal
Neurology
1526-632X
Publisher
Ovid Technologies (Wolters Kluwer) - American Academy of Neurology
Publication Date
Volume
66
Issue
12
Pages
1935–1937
Identifiers
PMID: 16801665
Source
Medline
License
Unknown

Abstract

The authors measured brain atrophy in nine patients undergoing immunoablation and autologous hematopoietic stem cell transplantation for multiple sclerosis. From baseline to 1 month after treatment, atrophy was 10 times faster than before treatment. A patient with non-CNS lymphoma showed comparable acute brain atrophy after analogous therapy. These observations suggest that brain atrophy after immunoablation may not be due entirely to the resolution of edema but may be related to chemotoxicity.

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