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BRAF V600E mutations: a series of case reports in patients with non-small cell lung cancer.

Authors
  • Goldman, Jamie M
  • Gray, Jhanelle E
Type
Published Article
Journal
Cancer Genetics
Publisher
Elsevier
Publication Date
Jun 01, 2015
Volume
208
Issue
6
Pages
351–354
Identifiers
DOI: 10.1016/j.cancergen.2015.04.001
PMID: 26066373
Source
Medline
Keywords
License
Unknown

Abstract

We present a series of five patients with BRAF-mutated non-small cell lung cancer (NSCLC) from the Moffitt Cancer Center and a brief literature review. Information utilized included outside medical records, imaging studies, pathology reports in which simultaneous mutation testing was performed, and clinic visit notes. In addition, we conducted a literature search of background information using the following search terms: "BRAF mutations", "non-small cell lung cancer", and "driver mutations". Several retrospective studies on BRAF mutations in patients with NSCLC found that the majority of these mutations occur in adenocarcinomas and are V600E mutations. From our patients and literature search, we found that BRAF-V600E mutations occur predominantly in female smokers with adenocarcinomas.

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