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BRAF Non-V600E Mutated Metastatic Colorectal Cancer in a Young Patient: Discussion from a Case Report

Authors
  • Moisset, Laure
  • Raimbourg, Judith
  • Hiret, Sandrine
  • Dauve, Jonathan
  • Boisdron-Celle, Michèle
  • Senellart, Hélène
  • Raoul, Jean-Luc
Type
Published Article
Journal
Case Reports in Oncology
Publisher
S. Karger AG
Publication Date
Jun 05, 2019
Volume
12
Issue
2
Pages
426–429
Identifiers
DOI: 10.1159/000500857
PMID: 31244646
PMCID: PMC6587192
Source
Karger
Keywords
License
Green
External links

Abstract

We report the case of a 32-year-old man with a caecal adenocarcinoma with major lymph node extension and peritoneal carcinomatosis, presenting a BRAF-K601E mutation. A triplet (5FU plus oxaliplatin plus irinotecan) combination with bevacizumab achieved tumor control but the disease progressed immediately after cessation and the patient died 8 months after the diagnosis. A short review of BRAF non-V600E mutations shows that outcome and clinical features depend on the mutation.

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