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BRAF mutation testing of thyroid fine-needle aspiration specimens enhances the predictability of malignancy in thyroid follicular lesions of undetermined significance.

Authors
  • Adeniran, Adebowale J
  • Hui, Pei
  • Chhieng, David C
  • Prasad, Manju L
  • Schofield, Kevin
  • Theoharis, Constantine
Type
Published Article
Journal
Acta cytologica
Publication Date
Jan 01, 2011
Volume
55
Issue
6
Pages
570–575
Identifiers
DOI: 10.1159/000333274
PMID: 22156468
Source
Medline
License
Unknown

Abstract

The sensitivity and specificity of BRAF mutation in detecting PTC in FNA specimens with indeterminate diagnosis was 59.3 and 100%, respectively, while the positive and negative predictive values were 100 and 65.6%, respectively. The limited data supports the use of BRAF mutation analysis to predict the risk of malignancy in patients with indeterminate thyroid FNAs.

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