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BPROMPT: A consensus server for membrane protein prediction.

Authors
  • Taylor, Paul D
  • Attwood, Teresa K
  • Flower, Darren R
Type
Published Article
Journal
Nucleic Acids Research
Publisher
Oxford University Press
Publication Date
Jul 01, 2003
Volume
31
Issue
13
Pages
3698–3700
Identifiers
PMID: 12824397
Source
Medline
License
Unknown

Abstract

Protein structure prediction is a cornerstone of bioinformatics research. Membrane proteins require their own prediction methods due to their intrinsically different composition. A variety of tools exist for topology prediction of membrane proteins, many of them available on the Internet. The server described in this paper, BPROMPT (Bayesian PRediction Of Membrane Protein Topology), uses a Bayesian Belief Network to combine the results of other prediction methods, providing a more accurate consensus prediction. Topology predictions with accuracies of 70% for prokaryotes and 53% for eukaryotes were achieved. BPROMPT can be accessed at http://www.jenner.ac.uk/BPROMPT.

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