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Bovine papillomavirus type 2 infects the urinary bladder of water buffalo (Bubalus bubalis) and plays a crucial role in bubaline urothelial carcinogenesis.

Authors
  • Roperto, Sante
  • Russo, Valeria
  • Ozkul, Ayhan
  • Sepici-Dincel, Aylin
  • Maiolino, Paola
  • Borzacchiello, Giuseppe
  • Marcus, Ioan
  • Esposito, Iolanda
  • Riccardi, Marita Georgia
  • Roperto, Franco
Type
Published Article
Journal
Journal of General Virology
Publisher
Microbiology Society
Publication Date
Feb 01, 2013
Volume
94
Issue
Pt 2
Pages
403–408
Identifiers
DOI: 10.1099/vir.0.047662-0
PMID: 23100367
Source
Medline
License
Unknown

Abstract

Bovine papillomavirus type 2 (BPV-2) has been shown to infect and play a role in urinary bladder carcinogenesis of buffaloes grazed on pastures with ferns from the Marmara and Black Sea Regions of Turkey. BPV-2 DNA has been found in both neoplastic and non-neoplastic lesions of the urinary bladder. Furthermore, this virus may be a normal inhabitant of the urinary bladder since BPV-2 DNA has also been detected in clinically normal buffaloes. The viral activation by fern immunosuppressant or carcinogen may trigger the urothelial cell transformation. The E5 oncoprotein was solely detected in urothelial tumours and appeared to be co-localized with the overexpressed and phosphorylated platelet derived growth factor (PDGF) β receptor in a double-colour immunofluorescence assay. Our results indicate that the E5-PDGF β receptor interaction also occurs in spontaneous tumours of the bubaline urinary bladder, revealing an additional role of BPV-2 in bladder carcinogenesis of buffaloes.

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