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Bovine leukemia virus-associated antigens in lymphocyte cultures.

Authors
  • Driscoll, D M
  • Olson, C
Type
Published Article
Journal
American Journal of Veterinary Research
Publisher
American Veterinary Medical Association
Publication Date
Nov 01, 1977
Volume
38
Issue
11
Pages
1897–1898
Identifiers
PMID: 201202
Source
Medline
License
Unknown

Abstract

Short-term lymphocyte cultures from bovine leukemia virus (BLV)-infected cattle were tested for BLV-associated antigens at various times after incubation. Several immunologic methods were used, including fluorescent antibody tests, immunodiffusion, and radial immunodiffusion. Antigens were not detected in uncultured lymphocytes. The BLV-associated antigens were detected as early as 3 hours, with maximum antigen production occurring at 18 to 24 hours after incubation. These results indicate that culturing of lymphocytes in vitro is necessary for the expression of the virus.

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