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Boronate-Based Probes for Biological Oxidants: A Novel Class of Molecular Tools for Redox Biology

Authors
  • Sikora, Adam1
  • Zielonka, Jacek2
  • Dębowska, Karolina1
  • Michalski, Radosław1
  • Smulik-Izydorczyk, Renata1
  • Pięta, Jakub1
  • Podsiadły, Radosław3
  • Artelska, Angelika1
  • Pierzchała, Karolina1
  • Kalyanaraman, Balaraman2
  • 1 Faculty of Chemistry, Institute of Applied Radiation Chemistry, Lodz University of Technology, Lodz , (Poland)
  • 2 Department of Biophysics and Free Radical Research Center, Medical College of Wisconsin, Milwaukee, WI , (United States)
  • 3 Faculty of Chemistry, Institute of Polymer and Dye Technology, Lodz University of Technology, Lodz , (Poland)
Type
Published Article
Journal
Frontiers in Chemistry
Publisher
Frontiers Media S.A.
Publication Date
Sep 25, 2020
Volume
8
Identifiers
DOI: 10.3389/fchem.2020.580899
PMID: 33102447
PMCID: PMC7545953
Source
PubMed Central
Keywords
License
Unknown

Abstract

Boronate-based molecular probes are emerging as one of the most effective tools for detection and quantitation of peroxynitrite and hydroperoxides. This review discusses the chemical reactivity of boronate compounds in the context of their use for detection of biological oxidants, and presents examples of the practical use of those probes in selected chemical, enzymatic, and biological systems. The particular reactivity of boronates toward nucleophilic oxidants makes them a distinct class of probes for redox biology studies. We focus on the recent progress in the design and application of boronate-based probes in redox studies and perspectives for further developments.

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