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BoneNET: a network model of bone microstructure and dynamics.

Authors
  • Kim, Taehyong
  • Bone, Lawrence
  • Ramanathan, Murali
  • Zhang, Aidong
Type
Published Article
Journal
International journal of data mining and bioinformatics
Publication Date
Jan 01, 2013
Volume
8
Issue
2
Pages
123–149
Identifiers
PMID: 24010264
Source
Medline
License
Unknown

Abstract

We develop a network model of bone microstructure and dynamics, BoneNET, which is capable of quantitative assessment of Bone Mineral Density (BMD) and bone remodelling dynamics. First, we introduce a network model of bone microstructure by describing structural properties and process of bone network modelling. Secondly, we explain a mathematical model of bone microstructure by analysing the density for mineralised fibres of bone microstructure. Finally, we provide a bone remodelling dynamics among osteoblast and osteoclast and study bone networks by proposing several measurements to calculate bone strength and identify critical elements in bone microstructure.

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