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Bone mineral density, biochemical and hormonal profiles in suboptimally treated children and adolescents with beta-thalassaemia disease.

Authors
  • Mahachoklertwattana, Pat
  • Chuansumrit, Ampaiwan
  • Sirisriro, Rojana
  • Choubtum, Lulin
  • Sriphrapradang, Arporn
  • Rajatanavin, Rajata
Type
Published Article
Journal
Clinical endocrinology
Publication Date
Mar 01, 2003
Volume
58
Issue
3
Pages
273–279
Identifiers
PMID: 12608931
Source
Medline
License
Unknown

Abstract

Patients with undertransfused severe beta-thalassaemia had more bone marrow expansion, lower serum IGF-1 levels and more delayed bone age than did patients with untransfused moderately severe beta-thalassaemia. Therefore, the severity of the disease appeared to be a primary factor for low bone mineral density in undertransfused patients in association with bone age delay and low serum IGF-1.

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