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Bone metabolism markers and bone mass in healthy pubertal boys and girls.

Authors
Type
Published Article
Journal
Clinical endocrinology
Publication Date
Volume
57
Issue
1
Pages
107–116
Identifiers
PMID: 12100078
Source
Medline
License
Unknown

Abstract

Our data suggest that bone metabolism markers are good predictors of bone mass in boys and of bone mass increase in both sexes. In early puberty, sex steroids stimulate the pubertal growth spurt in conjunction with GH and IGF-1. The fast increase in height gives rise to an increase in bone turnover and bone mineral apposition. It is known that at the end of puberty high levels of oestradiol inhibit chondrocyte proliferation. This leads to a decline in height velocity and bone turnover. Bone mass still increases under the influence of sex steroids and IGF-1. The data in our study confirm previous reports that markers of bone turnover relate positively to height velocity.

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