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Bone metabolism in children with human immunodeficiency virus infection receiving highly active anti-retroviral therapy including a protease inhibitor.

Authors
Type
Published Article
Journal
The Journal of Pediatrics
0022-3476
Publisher
Elsevier
Publication Date
Volume
139
Issue
3
Pages
447–451
Identifiers
PMID: 11562628
Source
Medline
License
Unknown

Abstract

We measured serum osteocalcin levels in prepubertal children with human immunodeficiency virus (HIV) infection receiving highly active antiretroviral therapy including a protease inhibitor and uninfected control children. Osteocalcin values were significantly elevated in the HIV-infected patients. Though osteocalcin serves as an index of bone formation, it likely functions as a negative regulator of bone formation. Further study is necessary to determine whether protease inhibitors normalize bone physiology or decrease bone formation and reduce bone mineral density in children receiving these therapies.

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