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Bone Material Strength Index as Measured by Impact Microindentation in Postmenopausal Women With Distal Radius and Hip Fractures.

Authors
  • Rozental, Tamara D1, 2
  • Walley, Kempland C1
  • Demissie, Serkalem3
  • Caksa, Signe4
  • Martinez-Betancourt, Adriana4
  • Parker, Amber M1
  • Tsai, Joy N4, 5
  • Yu, Elaine W4, 5
  • Bouxsein, Mary L1, 2, 4
  • 1 Department of Orthopedic Surgery, Beth Israel Deaconess Medical Center, Boston, MA, USA. , (Israel)
  • 2 Department of Orthopedic Surgery, Harvard Medical School, Boston, MA, USA.
  • 3 Department of Biostatistics, School of Public Health, Boston University, Boston, MA, USA.
  • 4 Endocrine Unit, Massachusetts General Hospital, Boston, MA, USA.
  • 5 Department of Medicine, Harvard Medical School, Boston, MA, USA.
Type
Published Article
Journal
Journal of Bone and Mineral Research
Publisher
Wiley (John Wiley & Sons)
Publication Date
Apr 01, 2018
Volume
33
Issue
4
Pages
621–626
Identifiers
DOI: 10.1002/jbmr.3338
PMID: 29115684
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

We tested whether cortical bone tissue properties assessed by in vivo impact microindentation would distinguish postmenopausal women with recent distal radius (DRF) or hip fracture (HF) from nonfracture controls (CONT). We enrolled postmenopausal women with recent DRF (n = 57), HF (n = 41), or CONT (n = 93), and used impact microindentation to assess bone material strength index (BMSi) at the anterior surface of the mid-tibia diaphysis. Areal bone mineral density (aBMD) (g/cm2 ) of the femoral neck (FN), total hip (TH), and lumbar spine (LS) were measured by dual-energy X-ray absorptiometry (DXA). HF and DRF subjects had significantly lower BMD than CONT at all sites (-5.6% to -8.2%, p < 0.001 for all). BMSi was 4% lower in DRF compared to CONT (74.36 ± 8.77 versus 77.41 ± 8.79, p = 0.04). BMSi was similarly lower in HF versus CONT, but the difference did not reach statistical significance (74.62 ± 8.47 versus 77.41 ± 8.79, p = 0.09). Lower BMSi was associated with increased risk of DRF (unadjusted OR, 1.43; 95% CI, 1.02 to 2.00, per SD decrease, p = 0.04), and remained statistically significant after adjustment for age, age and BMI, and age, BMI, and FN BMD (OR = 1.48 to 1.55). Lower BMSi tended to be associated with HF, but only reached borderline significance (unadjusted OR = 1.39; 95% CI, 0.96 to 2.01, p = 0.08). These results provide strong rationale for future investigations aimed at assessing whether BMSi can predict fracture in prospective studies and improve identification of women at risk for fragility fractures. © 2017 American Society for Bone and Mineral Research. © 2017 American Society for Bone and Mineral Research.

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