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Bone mass regulation of leptin and postmenopausal osteoporosis with obesity.

Authors
Type
Published Article
Journal
Clinical cases in mineral and bone metabolism : the official journal of the Italian Society of Osteoporosis, Mineral Metabolism, and Skeletal Diseases
Publication Date
Volume
9
Issue
3
Pages
145–149
Identifiers
PMID: 23289027
Source
Medline
Keywords
  • Opg
  • Rankl
  • Estrogen
  • Leptin
  • Leptin Receptor

Abstract

There are similarities in the mechanism between estrogen and leptin in influencing the process of bone remodeling. It may be considered that the role of estrogen can be replaced by leptin. Molecular genetic aspects that play a role in bone remodeling, such as leptin, leptin receptors, cytokines (e.g. RANK, RANKL, and OPG), require further study to be useful, especially regarding osteoporosis therapy based on genetic analysis.

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