Affordable Access

Bone mass measured by photonabsorptiometry and radiogrammetry in Wistar rats. Age and sex variations.

Authors
Type
Published Article
Journal
Investigative Radiology
0020-9996
Publisher
Ovid Technologies (Wolters Kluwer) - Lippincott Williams & Wilkins
Publication Date
Volume
21
Issue
4
Pages
336–339
Identifiers
PMID: 3700047
Source
Medline
License
Unknown

Abstract

Using radiogrammetric and photonabsorptiometric methods, we determined changes in bone mass in Wistar rats as a function of age and sex. In the four age groups studied (10-, 18-, 30-, and 78-week-old rats), males displayed greater bone mass than females. With increasing age, bone mass also increases up to the 78th week. However, the rate of this increase was slower in the 78-week age group. Whereas the length and periosteal diameter of the bones studied were increased in old age groups, the endosteal diameter decreased in females and increased in males. The results show that, unlike human bone, rat bone mass persistently increases with aging, and female rats continue to gain bone at the endosteal site. Furthermore, these findings demonstrate that radiogrammetric morphometry and photonabsorptiometry may be used as an experimental tool to investigate bone mass changes in small animals.

Statistics

Seen <100 times