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Bone Marrow Necrosis in Newly Diagnosed Acute Leukemia: Two Case Reports and Review of the Literature

Authors
  • Quintela, Adrien1
  • Sujobert, Pierre2
  • Tigaud, Isabelle3
  • Hayette, Sandrine2
  • Ffrench, Martine1
  • Salles, Gilles1
  • Thomas, Xavier1
  • Plesa, Adriana4
  • 1 Hospices Civils de Lyon, Department of Hematology, CHU Lyon-Sud Hospital, Lyon, France , Lyon (France)
  • 2 Hospices Civils de Lyon, Laboratory of Molecular Biology, CHU Lyon-Sud Hospital, Lyon, France , Lyon (France)
  • 3 Hospices Civils de Lyon, Laboratory of Cytogenetics, CHU Lyon-Sud Hospital, Lyon, France , Lyon (France)
  • 4 Hospices Civils de Lyon, Laboratory of Hematology and Flow Cytometry, CHU Lyon-Sud Hospital, Lyon, France , Lyon (France)
Type
Published Article
Journal
Oncology and Therapy
Publisher
Springer Healthcare
Publication Date
Feb 09, 2017
Volume
5
Issue
1
Pages
111–118
Identifiers
DOI: 10.1007/s40487-017-0041-7
Source
Springer Nature
Keywords
License
Green

Abstract

Bone marrow necrosis (BMN) in acute leukemia is a rare histopathological entity at the time of initial diagnosis. However, it represents an important diagnostic and prognostic challenge. Two cases of BMN are reported: a 44-year-old patient with B cell precursor (BCP) acute lymphoblastic leukemia (ALL) and a 27-year-old man with FAB-M5 acute myeloid leukemia (AML) who both presented with bone marrow failure and extensive necrosis. From these clinical cases, we conducted a brief review of the literature.

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