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Bone marrow mesenchymal stromal cell therapy for external urethral sphincter restoration in a rat model of stress urinary incontinence.

Authors
  • Corcos, Jacques
  • Loutochin, Oleg
  • Campeau, Lysanne
  • Eliopoulos, Nicoletta
  • Bouchentouf, Manaf
  • Blok, Bertil
  • Galipeau, Jacques
Type
Published Article
Journal
Neurourology and Urodynamics
Publisher
Wiley (John Wiley & Sons)
Publication Date
Mar 01, 2011
Volume
30
Issue
3
Pages
447–455
Identifiers
DOI: 10.1002/nau.20998
PMID: 21412824
Source
Medline
License
Unknown

Abstract

Rat MSCs have the ability to differentiate and skew their phenotype towards smooth and striated muscles, as demonstrated by SMA up-regulation and desmin expression. Periurethral injection of MSCs in an animal model of SUI restored the damaged external urethral sphincter and significantly improved VLPP.

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