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Bone marrow fat fraction assessment in regard to physical activity: KORA FF4-3-T MR imaging in a population-based cohort.

Authors
  • Bertheau, Robert C1
  • Lorbeer, Roberto2
  • Nattenmüller, Johanna1
  • Wintermeyer, Elke3
  • Machann, Jürgen4, 5, 6
  • Linkohr, Birgit7
  • Peters, Annette6, 7, 8, 9
  • Bamberg, Fabian10
  • Schlett, Christopher L11, 12
  • 1 Department of Radiology, Diagnostic and Interventional Radiology, University of Heidelberg, Heidelberg, Germany. , (Germany)
  • 2 Department of Radiology, Ludwig-Maximilian-University Hospital, Munich, Germany. , (Germany)
  • 3 Siegfried Weller Institute for Trauma Research, BG Trauma Center Tübingen, Eberhard Karls University Tuebingen, Tuebingen, Germany. , (Germany)
  • 4 Department of Diagnostic and Interventional Radiology, Section on Experimental Radiology, University Hospital Tuebingen, Tuebingen, Germany. , (Germany)
  • 5 Institute for Diabetes Research and Metabolic Diseases (IDM) of the Helmholtz Center Munich, University of Tuebingen, Tuebingen, Germany. , (Germany)
  • 6 Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Neuherberg, Germany. , (Germany)
  • 7 German Center for Diabetes Research (DZD), Neuherberg, Germany. , (Germany)
  • 8 German Center for Cardiovascular Disease Research (DZHK e.V.), Munich, Germany. , (Germany)
  • 9 Institute for Cardiovascular Prevention, Ludwig-Maximilian-University-Hospital, Munich, Germany. , (Germany)
  • 10 Department of Diagnostic and Interventional Radiology, Medical Center - Faculty of Medicine, University of Freiburg, Hugstetter Straße 55, 79106, Freiburg, Germany. , (Germany)
  • 11 Department of Radiology, Diagnostic and Interventional Radiology, University of Heidelberg, Heidelberg, Germany. [email protected] , (Germany)
  • 12 Department of Diagnostic and Interventional Radiology, Medical Center - Faculty of Medicine, University of Freiburg, Hugstetter Straße 55, 79106, Freiburg, Germany. [email protected] , (Germany)
Type
Published Article
Journal
European Radiology
Publisher
Springer-Verlag
Publication Date
Feb 21, 2020
Identifiers
DOI: 10.1007/s00330-019-06612-y
PMID: 32086579
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

To establish the effect of different degrees and kinds of physical activity on bone marrow fat (BMAT) content at different anatomical locations in a population-based cohort study undergoing whole-body MR imaging. Subjects of the KORA FF4 study without known cardiovascular disease underwent BMAT fat fraction (FF) quantification in L1 and L2 vertebrae and femoral heads/necks (hip) via a 2-point T1-weighted VIBE Dixon sequence. BMAT-FF was calculated as mean value (fat image) divided by mean value (fat + water image). Physical activity was determined by self-assessment questionnaire regarding time spent exercising, non-exercise walking, non-exercise cycling, and job-related physical activity. A total of 385 subjects (96% of 400 available; 56 ± 9.1 years; 58% male) were included in the analysis. Exercise was distributed quite evenly (29% > 2 h/week; 31% ~ 1 h/week (regularly); 15% ~ 1 h/week (irregularly); 26% no physical activity). BMAT-FF was 52.6 ± 10.2% in L1, 56.2 ± 10.3% in L2, 87.4 ± 5.9% in the right hip, and 87.2 ± 5.9% in the left hip (all p < 0.001). Correlation of BMAT-FF between spine and hip was only moderate (r 0.42 to 0.46). Spinal BMAT-FF, but not hip BMAT-FF, was inversely associated with exercise > 2 h/week (p ≤ 0.02 vs. p ≥ 0.35, respectively). These associations remained significant after adjusting for age, gender, waist circumference, and glucose tolerance. No coherent association was found between BMAT-FF and physical activity in the less active groups. In our study, exercise was inversely correlated with vertebral BMAT-FF, but not hip BMAT-FF, when exercising for more than 2 h per week. Physical activity seems to affect the spine at least preferentially compared to the hip. • In our population-based cohort, at least 2 h of physical activity per week were required to show lower levels of bone marrow adipose tissue fat fraction in MRI. • Physical activity seems to affect bone marrow adipose tissue at least preferentially at the spine in contrast to the proximal femur.

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