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Bone marrow chimerism and tolerance induced by single-dose cyclophosphamide.

Authors
  • Okayama, Junji1
  • Ko, Saiho
  • Kanehiro, Hiromichi
  • Kanokogi, Hideki
  • Hisanaga, Michiyoshi
  • Ohashi, Kazuo
  • Sho, Masayuki
  • Nagao, Mitsuo
  • Ikeda, Naoya
  • Kanamura, Tetsuhiro
  • Akashi, Satoru
  • Nakajima, Yoshiyuki
  • 1 First Department of Surgery, Nara Medical University, 840 Shijo-cho, Kashihara, Nara 634-8522, Japan.
Type
Published Article
Journal
The Journal of surgical research
Publication Date
July 2004
Volume
120
Issue
1
Pages
102–110
Identifiers
PMID: 15172196
Source
Medline
License
Unknown

Abstract

A single dose of CYP can induce hematopoietic chimerism across MHC-barriers. The dose of 150 mg/kg seems to be optimal to induce organ transplant tolerance without developing GVHD.

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