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Bone lesions in recurrent glucagonoma: A case report and review of literature.

Authors
Type
Published Article
Journal
World journal of gastrointestinal oncology
Publication Date
Volume
4
Issue
6
Pages
152–155
Identifiers
DOI: 10.4251/wjgo.v4.i6.152
PMID: 22737277
Source
Medline
Keywords
  • Blastic Lesion
  • Bone Metastases
  • Glucagonoma
  • Octreoscan

Abstract

Glucagonomas are rare neuroendocrine tumors that arise from α cells of the pancreatic islets. Most of them are malignant and usually present as metastatic disease. Sites most commonly involved in metastases are the liver and regional lymph nodes. Bone metastases are rare events and only a few cases have been reported in the literature. We present the case of a 53-year-old male with a medical history of recurrent non-functioning glucagonoma. He presented 17 years after the initial diagnosis with new blastic bone lesions involving the T1 vertebra and the sacrum. Diagnostic steps and medical management in metastatic glucagonoma are also reviewed.

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