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Bone cell interactions with a granular glass-ionomer bone substitute material: in vivo and in vitro culture models.

Authors
  • Brook, I M1
  • Craig, G T
  • Hatton, P V
  • Jonck, L M
  • 1 University of Sheffield, School of Clinical Dentistry, UK.
Type
Published Article
Journal
Biomaterials
Publisher
Elsevier
Publication Date
Jan 01, 1992
Volume
13
Issue
10
Pages
721–725
Identifiers
PMID: 1420719
Source
Medline
License
Unknown

Abstract

The interface between bone and a synthetic bone substitute constructed from glass-ionomer cement (ionomeric microimplant) was studied in diffusion chambers implanted in a primate baboon model (Papio ursinus) and in in vitro primary bone organ cultures derived from neonate rat calvaria. In both models osteoblast-like cells colonized the surface of the implant producing a collagenous extracellular matrix. An electron-dense bonding zone similar to that reported for hydroxyapatite and titanium was seen in both models but was a more constant feature of the tissue/implant interface in calvarial culture.

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