Bone cell interactions with a granular glass-ionomer bone substitute material: in vivo and in vitro culture models.
University of Sheffield, School of Clinical Dentistry, UK.
- Published Article
- Publication Date
Jan 01, 1992
The interface between bone and a synthetic bone substitute constructed from glass-ionomer cement (ionomeric microimplant) was studied in diffusion chambers implanted in a primate baboon model (Papio ursinus) and in in vitro primary bone organ cultures derived from neonate rat calvaria. In both models osteoblast-like cells colonized the surface of the implant producing a collagenous extracellular matrix. An electron-dense bonding zone similar to that reported for hydroxyapatite and titanium was seen in both models but was a more constant feature of the tissue/implant interface in calvarial culture.
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The corresponding record at NLM can be accessed at https://www.ncbi.nlm.nih.gov/pubmed/1420719