This study investigated the effect of dentin-desensitizing treatment with a casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) paste on shear bond strength (SBS) of two types of self-adhering (SA) restorative materials: resin-modified glass-ionomer (Fuji II LC, GC) and self-adhering flowable composite resin (Vertise Flow, Kerr). Flat and smear layer-free dentin surfaces from 48 extracted molars were prepared and divided into four groups (n = 12 per group) according to Fuji II LC or Vertise Flow and CPP-ACP pretreatment or not. After SBS testing, data were statistically analyzed. The adhesive interfaces were examined by scanning electron microscopy. SBS was significantly affected by CPP-ACP treatment (P < .001) and SA material (P < .05). The interaction of the two factors was not significant. The results suggested that the CPP-ACP pretreatment of the exposed dentin could have a beneficial effect on bonding ability and interfacial integrity of both SA materials so that intimately adapted interfaces were observed in CPP-ACP groups.