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BOMET-QoL-10 questionnaire for breast cancer patients with bone metastasis: the prospective MABOMET GEICAM study

  • Barnadas, A.1, 2
  • Muñoz, M.3
  • Margelí, M.4
  • Chacón, J. I.5
  • Cassinello, J.6
  • Antolin, S.7
  • Adrover, E.8
  • Ramos, M.9
  • Carrasco, E.10
  • Jimeno, M. A.10
  • Ojeda, B.1
  • González, X.11
  • González, S.12
  • Constenla, M.13
  • Florián, J.14
  • Miguel, A.15
  • Llombart, A.16
  • Lluch, A.2, 17
  • Ruiz-Borrego, M.18
  • Colomer, R.19
  • And 1 more
  • 1 Hospital de la Santa Creu I Sant Pau, C/Sant Antoni Maria Claret, 167, Barcelona, 08041, Spain , Barcelona (Spain)
  • 2 Centro de Investigación Biomédica en Red de Oncología, CIBERONC-ISCIII, Madrid, Spain , Madrid (Spain)
  • 3 Hospital Clinic i Provincial, C/ Villarroel n° 170, 08036, Barcelona, Spain , Barcelona (Spain)
  • 4 Hospital Germans Trias i Pujol, Canyet s/n, 08916 Badalona, Barcelona, Spain , Barcelona (Spain)
  • 5 Hospital Virgen de la Salud, Avda. Barber, n° 30, Toledo, 45005, Spain , Toledo (Spain)
  • 6 Hospital General de Guadalajara, C/ Donantes de Sangre, s/n, Guadalajara, 19002, Spain , Guadalajara (Spain)
  • 7 Complejo Hospitalario U. A Coruña, C/ Xubias de Abaixo s/n, A Coruña, 15006, Spain , A Coruña (Spain)
  • 8 Complejo Hospitalario Universitario de Albacete, C/ Hermanos Falcó n° 37, Albacete, 02006, Spain , Albacete (Spain)
  • 9 Centro Oncológico de Galicia, C/ Doctor Camilo Veiras s/n, A Coruña, 15009, Spain , A Coruña (Spain)
  • 10 Avda. de los Pirineos n° 7, 28703 San Sebastián de los Reyes, Madrid, Spain , Madrid (Spain)
  • 11 Hospital General de Catalunya, Carrer de Pedro Pons 1, Sant Cugat del Valles, Barcelona, 08195, Spain , Sant Cugat del Valles (Spain)
  • 12 Hospital Mutua de Terrassa, Barcelona, Plaza del Dr. Robert n°5, Terrassa, Barcelona, 08221, Spain , Terrassa (Spain)
  • 13 Complejo Hospitalario De Pontevedra, Calle Mourente s/n, Pontevedra, Galicia, 36071, Spain , Pontevedra (Spain)
  • 14 Hospital Comarcal de Barbastro, Ctra. Nacional 240, s/n, Barbastro, Huesca, 22300, Spain , Barbastro (Spain)
  • 15 Hospital Althaia Manresa, C/ Dr. Joan Soler, s/n, Manresa, Barcelona, 08243, Spain , Manresa (Spain)
  • 16 Hospital Arnau de Vilanova, Avda. Alcalde Rovira Roure, 80, Lleida, 25198, Spain , Lleida (Spain)
  • 17 Hospital Clínico Universitario de Valencia, Biomedical Research Institute INCLIVA, Valencia, Spain , Valencia (Spain)
  • 18 Hospital Virgen del Rocío, Avda. Manuel Siurot, s/n, Sevilla, 41013, Spain , Sevilla (Spain)
  • 19 Hospital Universitario La Princesa, C/ Diego de León n° 62, Madrid, 28006, Spain , Madrid (Spain)
  • 20 Hospital U. Josep Trueta, Avda. De França s/n, Gerona, 17007, Spain , Gerona (Spain)
Published Article
Journal of Patient-Reported Outcomes
Springer International Publishing
Publication Date
Dec 21, 2019
DOI: 10.1186/s41687-019-0161-y
Springer Nature


BackgroundBone metastasis (BM) is the most common site of disease in metastatic breast cancer (MBC) patients. BM impacts health-related quality of life (HRQoL). We tested prospectively the psychometric properties of the Bone Metastasis Quality of Life (BOMET-QoL-10) measure on MBC patients with BM.MethodsPatients completed the BOMET-QoL-10 questionnaire, the Visual Analogue Scale (VAS) for pain, and a self-perceived health status item at baseline and at follow-up visits. We performed psychometric tests and calculated the effect size of specific BM treatment on patients´ HRQoL.ResultsAlmost 70% of the 172 patients reported symptoms, 23.3% experienced irruptive pain, and over half were receiving chemotherapy. BOMET-QoL-10 proved to be a quick assessment tool performing well in readability and completion time (about 10 min) with 0–1.2% of missing/invalid data. Although BOMET-QoL-10 scores remained fairly stable during study visits, differences were observed for patient subgroups (e.g., with or without skeletal-related events or adverse effects). Scores were significantly correlated with physician-reported patient status, patient-reported pain, symptoms, and perceived health status. BOMET-QoL-10 scores also varied prospectively according to changes in pain intensity.ConclusionsBOMET-QoL-10 performed well as a brief, easy-to-administer, useful, and sensitive HRQoL measure for potential use for clinical practice with MBC patients.Trial registrationNCT03847220. Retrospectively registered on (February the 20th 2019).

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