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Bombesin elicits satiety in sham feeding rats.

Authors
  • Martin, C F
  • Gibbs, J
Type
Published Article
Journal
Peptides
Publisher
Elsevier
Publication Date
Jan 01, 1980
Volume
1
Issue
2
Pages
131–134
Identifiers
PMID: 7243611
Source
Medline
License
Unknown

Abstract

The satiety effect of intraperitoneal injections of the synthetic tetradecapeptide bombesin (BBS) was examined in rats equipped with chronic gastric cannulas. BBS produced potent, dose-related suppressions of both sham feeding (on days when gastric cannulas were open) and feeding (on days when gastric cannulas were closed). BBS not only suppressed sham feeding, but also elicited the behavioral sequence characteristic of normal satiety. The results demonstrate the potency of BBS in eliciting behavioral satiety under conditions in which gastric, intestinal and postabsorptive mechanisms are minimally activated by ingested food. These findings are consistent with previous reports suggesting a role for BBS in satiety.

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