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Body mass, chronic heart failure, surgery and survival

Journal
The Journal of Heart and Lung Transplantation
Publisher
Elsevier
Publication Date
Jan 01, 2010
Volume
29
Issue
3
Identifiers
DOI: 10.1016/j.healun.2009.07.004
Keywords
Disciplines
  • Medicine
License
Unknown

Abstract

Cardiac cachexia, associated with excessive activation of the sympathetic nervous system together with immune activation, is an important prognostic indicator in heart failure. Anecdotally, the prevalence of cardiac cachexia appears to be falling, perhaps due to the increased use of beta-blockers. However, chronic heart failure is so common that many patients continue to lose weight and continue to deteriorate to a point where transplantation or mechanical support is considered. The origin of cachexia remains elusive and further research is needed to explore the relation between weight, sympathetic activation, and the response to cardiac surgery or transplantation.

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