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BNCT of 3 cases of spontaneous head and neck cancer in feline patients.

Authors
  • Rao, Mónica
  • Trivillin, Verónica A
  • Heber, Elisa M
  • Cantarelli, María de los Angeles
  • Itoiz, María E
  • Nigg, David W
  • Rebagliati, Raúl Jiménez
  • Batistoni, Daniel
  • Schwint, Amanda E
Type
Published Article
Journal
Applied Radiation and Isotopes
Publisher
Elsevier
Publication Date
Nov 01, 2004
Volume
61
Issue
5
Pages
947–952
Identifiers
PMID: 15308173
Source
Medline
License
Unknown

Abstract

Having demonstrated BPA-BNCT induced control of experimental squamous cell carcinomas (SCC) of the hamster cheek pouch mucosa with no damage to normal tissue we explored the feasibility and safety of treating spontaneous head and neck tumors, with particular focus on SCC, of terminal feline patients with low dose BPA-BNCT employing the thermal beam of the RA-1 Reactor within a preclinical context. The biodistribution studies showed that, in all three cases evaluated, BPA delivered absolute boron values to tumor in the range that proved therapeutically useful in the experimental model of SCC. BPA-BNCT studies showed no radiotoxic effects, partial tumor control in terms of impaired growth and partial necrosis, an improvement in clinical condition and prolonged survival beyond the terminal condition of the feline patients at the time of recruitment.

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