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BMP-2 but not VEGF or PDGF in fibrin matrix supports bone healing in a delayed-union rat model.

Authors
  • Kaipel, Martin
  • Schützenberger, Sebastian
  • Schultz, Arthur
  • Ferguson, James
  • Slezak, Paul
  • Morton, Tatjana J
  • Van Griensven, Martijn
  • Redl, Heinz
Type
Published Article
Journal
Journal of orthopaedic research : official publication of the Orthopaedic Research Society
Publication Date
Oct 01, 2012
Volume
30
Issue
10
Pages
1563–1569
Identifiers
DOI: 10.1002/jor.22132
PMID: 22508566
Source
Medline
License
Unknown

Abstract

Treatment of delayed bone healing and non-unions after fractures, osteotomies or arthrodesis still is a relevant clinical challenge. Artificially applied growth factors can increase bone healing and progressively gain importance in clinical routine. The aim of this study was to determine the effects of rhPDGF-BB, rhVEGF-165, and rhBMP-2 in fibrin matrix on bone healing in a delayed-union rat model. Thirty-seven rats underwent a first operation where a standardized femoral critical size defect was created. A silicone spacer was implanted to impair vascularization within the defect. At 4 weeks the spacer was removed in a second operation and rhPDGF-BB, rhVEGF-165, or rhBMP-2 were applied in a fibrin clot. Animals in a fourth group received a fibrin clot without growth factors. At 8 weeks fibrin bound rhBMP-2 treated animals showed a significantly increased union rate and bone volume within the defect compared to the other groups. Single application of fibrin bound rhPDGF-BB and rhVEGF-165 failed to increase bone healing in our atrophic non-union model.

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