Affordable Access

deepdyve-link
Publisher Website

Blood-testis barrier and spermatogenesis: lessons from genetically-modified mice.

Authors
  • Jiang, Xiao-Hua
  • Bukhari, Ihtisham
  • Zheng, Wei
  • Yin, Shi
  • Wang, Zheng
  • Cooke, Howard J
  • Shi, Qing-Hua
Type
Published Article
Journal
Asian Journal of Andrology
Publisher
Medknow Publications
Publication Date
Jan 01, 2014
Volume
16
Issue
4
Pages
572–580
Identifiers
DOI: 10.4103/1008-682X.125401
PMID: 24713828
Source
Medline
License
Unknown

Abstract

The blood-testis barrier (BTB) is found between adjacent Sertoli cells in the testis where it creates a unique microenvironment for the development and maturation of meiotic and postmeiotic germ cells in seminiferous tubes. It is a compound proteinous structure, composed of several types of cell junctions including tight junctions (TJs), adhesion junctions and gap junctions (GJs). Some of the junctional proteins function as structural proteins of BTB and some have regulatory roles. The deletion or functional silencing of genes encoding these proteins may disrupt the BTB, which may cause immunological or other damages to meiotic and postmeiotic cells and ultimately lead to spermatogenic arrest and infertility. In this review, we will summarize the findings on the BTB structure and function from genetically-modified mouse models and discuss the future perspectives.

Report this publication

Statistics

Seen <100 times