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Blood Sampling and Preparation Procedures for Proteomic Biomarker Studies of Psychiatric Disorders.

Authors
  • Guest, Paul C1
  • Rahmoune, Hassan2
  • 1 Department of Biochemistry and Tissue Biology, Laboratory of Neuroproteomics, Institute of Biology, University of Campinas (UNICAMP), Rua Monteiro Lobato 255 F/01, Cidade Universitária ZeferinoVaz, 13083-862, Campinas, Brazil. , (Brazil)
  • 2 Department of Chemical Engineering and Biotechnology, University of Cambridge, CB2 3RA, Cambridge, UK. [email protected]
Type
Published Article
Journal
Advances in experimental medicine and biology
Publication Date
Jan 01, 2017
Volume
974
Pages
141–147
Identifiers
DOI: 10.1007/978-3-319-52479-5_9
PMID: 28353230
Source
Medline
Keywords
License
Unknown

Abstract

A major challenge in proteomic biomarker discovery and validation for psychiatric diseases is the inherent biological complexity underlying these conditions. There are also many technical issues which hinder this process such as the lack of standardization in sampling, processing and storage of bio-samples in preclinical and clinical settings. This chapter describes a reproducible procedure for sampling blood serum and plasma that is specifically designed for maximizing data quality output in two-dimensional gel electrophoresis, multiplex immunoassay and mass spectrometry profiling studies.

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